MUDr. Tomáš Páleníček, Ph.D.
researcher, physician, lecturer, research assistant, head of research programme
working at:  Psychedelics Research Centre
v instituci:  2001 - present
e-mail: info.psycentre@nudz.cz
curriculum vitae


Dr. Palenicek has been employed at National Institute of Mental Health, Czech Republic (NIHM CR, formerly Prague Psychiatric Centre) since 2001. He started his career as a PhD student in preclinical research, studying the neurobiology of schizophrenia in animal models. Shortly after, he received his first grant funding and extended his research interests towards the neurobiology of psychedelic drugs (e.g., LSD, psilocin, mescaline, 2C-B), entactogens (ecstasy / MDMA) and new synthetic drugs. Simultaneous to working on his PhD he passed his training as a clinical psychiatrist with a specialism in clinical electroencephalography (EEG). He defended his thesis in early 2009 and in 2012 he became a licensed psychiatrist. Over the last few years he contributes significantly to human clinical research. He is involved as a co-investigator of ketamine projects in NIHM CR, where ketamine is used to model psychosis and to treat depression in humans. For the last four  years he is a principle investigator of the first project in the Czech Republic that is intended to study the acute effects of cannabis in healthy volunteers. Finally, he is also a principle investigator of the first human clinical trial in the Czech Republic studying the effects of psilocybin in human volunteers. Currently his research interests are oriented to the area of EEG functional connectivity. He  continues his clinical practice as a psychiatrist in local outpatient clinic.

Professional training and experience

1995 - 1997: Contact worker at the Contact Center for addicts (SANANIM)
1998 - 2001: Passing out the accredited group dynamic psychotherapeutic training SUR
1999 - 2000: Somatic and social consequences of drug use (superviser J. Pachl, MD, CSc.)
2000 - 2001: Research of neurobiological mechanisms of drug addiction using microdialysis in freely moving animals (supervisor Pharm.Dr. M. Fišerová, CSc.)
2001 - 2009: Postgradual studies (Ph.D.) in neurosciences ( 3rd Medical Faculty, Charles Univ, supervisor Prof. C. Höschl, DrSc.)
2001 - present: scientist at Prague psychiatric Center
2005: First Certificate in English (FCE)
2006: passing out the training allowing to work with altered states of consciousness (Stargate)
2006 - present: psychiatrist at Prague Psychiatric Center
2010: certification in electroencefalography (Clinical neurophysiology society and Neurological Society ČLS JEP)
2010 - present: certification in electroencefalography (Clinical neurophysiology society and Neurological Society ČLS JEP)

Membership in professional organizations

2003 - present: member of Czech Neuropsychopharmacological Association
2006 - present: Erowid.org member
2010 - present: member of International Pharmaco-EEG Group (IPEG)
2014 - present: member of European College of Neuropsychopharmacology (ECNP)
2014 - present: member of The International College of Neuropsychopharmacology (CINP)

Awards and honors

2008: ČNPS award for best poster presentation in the research field “Psychedelics” (50th Czech-Slovak psychopharmacological conference in Jeseník Spa in 9th -13th January 2008): Fujáková M., Rohanová M., Kutová M., Páleníček T., Balíková M., Brunovský M. Tišlerová B., Šóš P., Bubeníková-Valešová V. Farmakokinetika, behaviorální a QEEG účinky syntetického psychedelika 2C-B.
2009: Prof. Werner M. Herrmann Memorial Grant od International Pharmaco - EEG society (IPEG) for best poster within conference IPEG 2008, Rouffach, France during days 24.-27.10.2008: Palenicek T., Fujakova M., Kutova M., Brunovsky M., Horacek J., Sos P., Tislerova B., Bubenikova-Valesova V. Quantitative EEG in glutamatergic and dopaminergic models of psychosis – animal study
2010: ČNPS award for best clinical manuscript published in 2010: Horacek J, Brunovsky M, Novak T, Tislerova B, Palenicek T, Bubenikova-Valesova V, Spaniel F, Koprivova J, Mohr P, Balikova M, Hoschl C. Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect. Psychol Med., 2010; 40(9):1443-51
2010: CINP poster prize award from XXVII CINP Congress, 6 - 10 June 2010, Hong Kong: Páleníček, T., Brunovský, M., Horáček, J., Fujáková, M., Gorman, I., Tylš, F., Krajča, V. The effect of ketamine on sensorimotor gating, EEG spectra and coherence - comparison of human and animal data.
2010: CINP poster prize award from XXVII CINP Congress, 6 - 10 June 2010, Hong Kong: Fujáková, M., Páleníček, T., Brunovský, M., Bubeníková-Valešová, V., Gorman, I. A potential antipsychotic effect of group II metabotropic glutamate receptor agonist, LY379268, on behavioral changes and quantitative electroencephalography in rats in ketamine model of psychosis.

Specialization

2012 - 2012: licensed in Psychiatry

Teaching activities

2001 - present: assistent professor, teaching psychiatry at 3rd Faculty of Medicine, Charles University in Prague (psychiatry, phramcology, drug addiction)
2004: oponent of Tomáš Vejrych´s thesis "Extasy and free techno party"
2005 - 2006: tutor of Michaela Fujáková´s student scientific activity at 1st Faculty of Medicine, Charles University, Prague: "Influence of a Synthetic Drug 2C-B on EEG Spektrum and EEG Coherence in the Rat – A Potential Model of Psychosis?"
2005 - 2008: tutor of Martina Kutová´s thesis on Faculty of Natural Sciences, Charles University in Prague: "The Role of 5-HT1 and 5-HT2 Serotonin Receptors in Mechanism of Synthetic drug 2C-B Effect – Behavioural Study on Rats"
2005 - present: Assistent professor, teaching neurosciences at 1st Faculty of Medicine, Charles University in Prague, branch of addictology
2009 - 2010: tutor of Filip Tylš´s student scientific activity at 1st Faculty of Medicine, Charles University, Prague: "Animal models of psychosis – The role of AMPA glutamatergic receptors in neurobiology of schizophrenia"
2011 - present: tutor of postgradual students in Neurosciences on 3.LFUK

Thesis

2009: The role of dopaminergic and serotonergic neurotransmission in animal models of psychoses

Publications

Most important publications

GOODWIN, GM., AARONSON, ST., ALVAREZ, O., ARDEN, PC., BAKER, A., BENNETT, JC., BIRD, C., BLOM, RE., BRENNAN, Ch., BRUSCH, D., BURKE, L., CAMPBELL-COKER, K., CARHART-HARRIS, R., CATTELL, J., DANIEL, A., DEBATTISTA, Ch., DUNLOP, BW., EISEN, K., FEIFEL, D., FORBES, M., PÁLENÍČEK, T. Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression. New England Journal of Medicine. 2022, 387(18), 1637-1648. ISSN 0028-4793. DOI: 10.1056/NEJMoa2206443. IF 176.082.

ŠTEFKOVÁ-MAZOCHOVÁ, K., DANDA, H., DEHAEN, W., JURÁSEK, B., ŠÍCHOVÁ, K., PINTEROVÁ-LECA, N., MAZOCH, V., HRČKA KRAUSOVÁ, B., KYSILOV, B., SMEJKALOVÁ, T., VYKLICKÝ, L., KOHOUT, M., HÁJKOVÁ, K., SVOZIL, D., HORSLEY, RR., KUCHAŘ, M., PÁLENÍČEK, T. Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine (DCK) in Wistar rats. British Journal of Pharmacology. 2022, 179(1), 65-83. ISSN 0007-1188. DOI: 10.1111/bph.15680. IF 9.473.

MADSEN, KM., FISHER, PM., STENBÆK, DS., KRISTIANSEN, S., BURMESTER, D., LEHEL, S., PÁLENÍČEK, T., KUCHAŘ, M., SCARER, C., OZENNE, B., KNUDSEN, GM. A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. European Neuropsychopharmacology. 2020, 33(April), 71-80. ISSN 0924-977X. DOI: 10.1016/j.euroneuro.2020.02.001. IF 4.600.

PÁLENÍČEK, T., HLIŇÁK, Z., BUBENÍKOVÁ-VALEŠOVÁ, V., NOVÁK, T., HORÁČEK, J. Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2010, 34(4), 588-596. ISSN 0278-5846. DOI: 10.1016/j.pnpbp.2010.02.008. IF 2.877.

JIŘÍČEK, S., KOUDELKA, V., LACIK, J., VEJMOLA, Č., KURATKO, D., WOJCI, DK., RAIDA, Z., HLINKA, J., PÁLENÍČEK, T. Electrical Source Imaging in Freely Moving Rats: Evaluation of a 12-Electrode Cortical Electroencephalography System. Frontiers in Neuroinformatics. 2021, 14("Article number 589228"), 1-22. ISSN 1662-5196. DOI: 10.3389/fninf.2020.589228. IF 4.081.


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