Clinical Research Program

Head of the department
MUDr. Martin Brunovský, Ph.D.
Markéta Doležalová (coordinator)
telephone:(+420) 283 088 437


The main aim of the Programme is clinically oriented research on the neurobiological basis of mood disorders, anxiety disorders, psychotic disorders and cognitive disorders. It uses a comprehensive integration of clinical data with the results of neuropsychological, electrophysiological, and brain imaging studies to elucidate the nature of mental disorders and the associated more precise targeting of treatments. The research program provides a state-of-the-art facility for investigating the dynamics of complex brain processes under normal and pathological conditions and changes induced by various therapeutic modalities.

The department is a pivotal base for the application of a wide range of electrophysiological and neuroimaging methods (high-density EEG, MRI/fMRI) studying diverse brain processes (neuronal oscillations, brain perfusion changes, sources of electromagnetic activity, functional and effective connectivity) and their disruption in neuropsychiatric diseases, with the aim of developing early diagnostic indicators and predictors of therapeutic interventions. By combining imaging, stimulation and behavioral methods, it contributes to the detection, prevention and remediation of cognitive deficits as a risk factor for functional impairment. The research programme also provides support in neurophysiological methods, MRI scans and analyses to projects of other NIMH research centres and focuses on the use of modern non-invasive stimulation methods in brain research and therapy of mental disorders.


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